BENZALKONIUM CHLORIDE TASTE MASKING GRANULES
Benzethonium chloride appears as odorless white crystals or powder with a very bitter taste. Benzyldimethylamine is quaternized by a 2-[p-(2, 4, 4-trimethylpentan-2-yl) phenoxy] ethoxyethyl group in benzethonium chloride, a (synthetic) quaternary ammonium salt, with chloride serving as the counter-ion. It works as an antiseptic and disinfectant to kill a variety of bacteria, fungi, moulds, and viruses. It functions as a medicine that is antiseptic, disinfecting, antibacterial, antiviral, and antifungal. It consists of an aromatic ether, a chloride salt, and a quaternary ammonium salt. Benzalkonium chloride (BAC): BAC is a wide spectrum quaternary ammonium antibacterial agent that has been used in various dental composites.
PARTICLE SIZE
◉ Taste masked of Powder, Beads, Beadlets, Spheres, Granules, Pellets particle
◉ Size: 12/14#,14/18#,18/20#,16/20#,14/20#,20/30#,30/60#
◉ Aperture Micron: 1680-1410 µm, 1410-1000 µm,1000-841 µm,1190-841 µm,841-595 µm, 595-250 µm,250-75 µm
IUPAC NAME
◉ benzyl-dimethyl-[2-[2-[4-(2, 4, 4-trimethylpentan-2-yl) phenoxy] ethoxy] ethyl] azanium; chloride
DRUG CLASSIFICATION
◉ Category III antiseptic active ingredient
THERAPEUTIC ACTION
◉ Prior to surgical procedures or for minor wound care to reduce risks of infection, used for cold sore care, antiseptic and disinfectant, used as an antimicrobial preservative for pharmaceutical products
BENEFITS OF BENZALKONIUM CHLORIDE
- Adding a combination of sweeteners (sucralose, aspartame)
- Flavors (orange, mint) to mask the unpleasant taste of low to moderately bitter actives
- Taste masking increases drug acceptability and medication adherence in pediatric, geriatric, and other special patient populations
- Content uniformity with an excellent taste masking
- Reduce aversive sensory attributes
- To increases of bioavailability
- To alter drug release
- To produce a targeted drug delivery
- To decreases evaporation rate of core material
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