Encapsulation Technology
Encapsulation technology essentially deals with the incorporation of commercially available active material into protective system that can deliver the active to specific site. Skin, hair and mucosal surfaces are useful targets for the delivery of active compounds. The core is covered by solid shell which is used to deliver, protect stabilize or control the release of the core/active.
Protective Shell
- Usually selected from a list of materials 'generally regarded as safe' (GRAS) to meet the needs of the application as well as regulatory demands e.g.. Biodegradability - USP Grade
Core
- Ingredients - Encapsulated Includes : Colors, Fragrances, Flavors, Vitamins & Oils etc.
Target Delivery
- Skin, hair and mucosal surfaces are useful targets for the delivery of active compounds.
Reasons to Employ an Encapsulation
1.Superior handling of active material (e.g. conversion of liquid active agent into a powder). 2. Improved stability in final products during processing (e.g. less evaporation of volatile active). 3. Creation of visible effects. 4. Adjustable properties of active components (particle size, structure, oil or water soluble color. 5. Off taste masking. 6. Controlled release.
Types of Encapsulated Spheres
1. Pressure release / burst release / water penetration control system. 2. This is design as water as the main agent controlling the release of the active. 3. In this system active molecules cannot physically diffuse out the device without water molecule diffusing in 4. This is usually achieved by incorporating actives in hydrophilic polymer that is stiff when dry but swells when placed in aqueous environment.
pH Responsive Spheres
In this technique Spheres are coated with ionic pH sensitive polymers having as main feature that they release protons in response to pH change. Having a structure acid or basic groups that can accept or release protons in response to pH change in surrounding environment.
Color in Color Spheres
These Spheres gives color changing effect on rubbing. Color in color Spheres is a simple concept where in the core is of one color and the out shell can be of different color. The process consists essentially of spraying a color solution fluid on to particles of substrate material undergoing encapsulation. This is achieved by fluid bed coating.
Oil Encapsulation
The encapsulation method provided Spheres where oil droplets were well dispersed and protected. The wall material used commonly includes synthetic polymer and natural biomaterials (usually carbohydrates).
Flavor Encapsulation
Encapsulation of flavor and fragrance in dedicated shell. It can limit the degradation or loss of the flavor during the various product process and storage. The shell can also provide the functional properties such as control release of aromatic molecules in given environment.
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